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It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients. A 63-year-old man receiving allopurinol for gout developed progressive uremia, proteinuria, edema, and purpura after beginning quinidine therapy. Adverse effects can be minimized by increased hydration, urine alkalinization, and the prophylactic administration of a xanthine oxidase inhibitor such as ZYLOPRIM® (allopurinol). Allopurinol will not relieve a gout attack that has already started. In one study in mice, large amounts of allopurinol caused birth defects and other unwanted effects.

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